Refractive error is an umbrella term for short sight, long sight and astigmatism and other defects of the optical systems of the eye. UK Biobank collected data on refractive error using a Tomey RC 5000 auto refractor. This device also produces measurements of the curvature of the cornea, the clear structure at the front of the eye, and the major refracting interface in the eye's optical system.
Short-sightedness (myopia) in particular, as a model of a ‘complex’ eye disease (i.e. influenced by genes and the environment) we will investigate the complex relationships between both myopia and visual function and a diverse range of risk factors over the lifecourse. We aim to identify, where possible, risk factors that can be modified or biological processes and pathways that would merit further research. Our findings will provide information to support advocacy for equitable and appropriate allocation of resources for adults with impaired vision. This project will also extend the epidemiological and statistical approaches to studying complex ocular disorders that we have developed in prior research which ultimately will benefit ophthalmic epidemiology more generally.
