Rhegmatogenous retinal detachment (RRD) is a common sight threatening condition that affects over 7,000 people annually in the U.K. Several predisposing risk factors are known to be important, such as myopia, advancing age and ocular trauma. In previous work, we have demonstrated that several gene pathways influence the risk of developing RRD. The UKBiobank represents an unrivalled resource enabling detailed analyses in genetic risk and disease association to be performed. Using single nucleotide polymorphisms (SNPs), which are markers of genetic variation, we aim to extend our assembled genetic database and perform a larger, case-control genome wide association study on RRD cases and population-matched controls. This research has the potential to identify new pathways in the disease process and with this, the potential for new therapeutic targets aimed at the prevention or treatment of this blinding condition.